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Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

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Manifestaciones Clínicas

Taylor F Levine1, Genna M Mashinchi2, Emily Post1

  • 1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La inflamación afecta la memoria verbal de manera diferente en mujeres y hombres hispanos/latinos con cognición normal, y las mujeres muestran resiliencia al factor de necrosis tumoral alfa (TNF-α). Estas diferencias sexuales en la enfermedad de Alzheimer (EA) varían según la etnia.

Palabras clave:
Enfermedad de Alzheimerdiferencias sexualesinflamaciónmemoria verbaletniahispanoslatinosfactor de necrosis tumoral alfaresiliencia

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Área de la Ciencia:

  • Neurociencia
  • Inmunología
  • Gerontología

Sus antecedentes:

  • Las mujeres con enfermedad de Alzheimer (EA) muestran inicialmente ventajas en el aprendizaje verbal pero un declive más rápido.
  • Las diferencias sexuales en la progresión de la EA no se comprenden completamente, pero la inflamación puede desempeñar un papel.
  • Investigaciones anteriores en cohortes de personas blancas no hispanas (NHW) indicaron que la memoria verbal de las mujeres es robusta a la inflamación moderada.

Objetivo del estudio:

  • Investigar las diferencias sexuales en el impacto de la inflamación en el aprendizaje y la memoria verbales en una cohorte de enfermedad de Alzheimer (EA) étnicamente diversa.
  • Examinar cómo los marcadores inflamatorios (TNF-α, IL-6, IL-10) afectan la memoria verbal en personas hispanas/latinas (HL) y blancas no hispanas (NHW).
  • Hipotetizar que las mujeres cognitivamente normales (CN) mantendrán la memoria verbal a pesar de la inflamación, a diferencia de las mujeres con deterioro cognitivo leve (MCI).

Principales métodos:

  • Se analizaron datos de 661 participantes NHW y 631 HL en el Health and Aging Brain Study-Health Disparities.
  • Se evaluaron las diferencias sexuales longitudinales en la relación entre los marcadores inflamatorios del plasma y el aprendizaje/memoria verbal.
  • Se utilizó la Prueba de Aprendizaje Verbal en Español e Inglés para las medidas de aprendizaje y recuerdo diferido.

Principales resultados:

  • En personas hispanas/latinas (HL) con cognición normal (CN), la memoria verbal de las mujeres no se vio afectada por los niveles de factor de necrosis tumoral alfa (TNF-α), mientras que los hombres mostraron un declive (p=0.035). El sexo no moderó el efecto del TNF-α sobre la memoria verbal en personas HL con deterioro cognitivo leve (MCI). No se encontró una moderación sexual significativa del impacto de la inflamación en la memoria verbal en la cohorte de personas blancas no hispanas (NHW) para los grupos CN o MCI.

Conclusiones:

  • Las ventajas de las mujeres en el aprendizaje y la memoria verbal en la enfermedad de Alzheimer están influenciadas por la etnia y el marcador inflamatorio TNF-α.
  • Se requiere más investigación para comprender las variaciones étnicas en la resiliencia y la vulnerabilidad a la EA.
  • Es esencial investigar los factores causales de estos complejos patrones en los grupos raciales y étnicos.