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Manifestaciones Clínicas

Marnina B Stimmel1, Emmeline Ayers2, Joe Verghese2

  • 1Albert Einstein College of Medicine, Bronx, NY, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Ciertos ítems del Addenbrooke's Cognitive Examination-III (ACE-III) muestran altas tasas de error en adultos mayores sanos desde el punto de vista cognitivo, de habla malaya, en la India, especialmente aquellos con menor nivel educativo. Estos hallazgos sugieren una interpretación cautelosa de los resultados del ACE-III en esta población.

Palabras clave:
pruebas neuropsicológicaseducaciónpuntuaciónpoblaciónerroresdemenciaevaluacióndeterioro cognitivoadultos mayoresestudios longitudinales

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Área de la Ciencia:

  • Neurología; Ciencias Cognitivas; Gerontología

Sus antecedentes:

  • El aumento de las tasas mundiales de demencia requiere herramientas de cribado cognitivo validadas.
  • El Addenbrooke's Cognitive Examination-III (ACE-III) es una herramienta utilizada ampliamente para identificar el deterioro cognitivo.
  • Estudios previos indican posibles problemas con ítems específicos del ACE-III, particularmente en lo que respecta al nivel educativo.

Objetivo del estudio:

  • Evaluar el rendimiento de los ítems individuales del ACE-III en una cohorte de adultos mayores sanos desde el punto de vista cognitivo y de habla malaya en la India.
  • Identificar ítems específicos del ACE-III que puedan arrojar altas tasas de error en esta población.
  • Investigar la influencia del nivel educativo en el rendimiento de los ítems individuales del ACE-III.

Principales métodos:

  • Participaron 132 adultos mayores de habla malaya del Kerala Einstein Study.
  • Los participantes se sometieron a la versión malaya del ACE-III y a una batería neuropsicológica completa.
  • La normalidad cognitiva se determinó por consenso de expertos; la educación se dicotomizó (≥10 años frente a <10 años) para el análisis.

Principales resultados:

  • Varios ítems del ACE-III fueron acreditados universalmente (p. ej., orientación, repetición, comprensión).
  • Más del 25% de los participantes cometieron errores en ítems como el dibujo del reloj, la copia de cubos y el recuerdo de nombres/direcciones.
  • Un menor nivel educativo se asoció significativamente con mayores tasas de error en ítems específicos del ACE-III.

Conclusiones:

  • El ACE-III es una valiosa herramienta de cribado, pero ciertos ítems demuestran una utilidad limitada en adultos mayores sanos desde el punto de vista cognitivo y de habla malaya.
  • Las altas tasas de error en ítems específicos, particularmente entre aquellos con menor nivel educativo, exigen una interpretación cautelosa.
  • Los hallazgos subrayan la necesidad de considerar el historial educativo al interpretar el rendimiento del ACE-III para evitar diagnósticos erróneos.