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Sulakshna Aggarwal1, Priya Chatterjee2, Hitesh Pradhan2

  • 1Centre for Brain Research, Bangalore, Karnataka, India.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los niveles elevados de homocisteína se asocian con una peor función cognitiva y volúmenes cerebrales reducidos en adultos rurales indios, independientemente del estado de la vitamina B12. El cribado temprano de homocisteína puede ayudar a identificar a las personas en riesgo de deterioro cognitivo.

Palabras clave:
homocisteínadeterioro cognitivovitamina B12volumen cerebralIndia rural

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Área de la Ciencia:

  • Neurología
  • Neurociencia Nutricional
  • Gerontología

Sus antecedentes:

  • La vitamina B12 influye en la función cognitiva, potencialmente a través de los niveles de homocisteína.
  • Existen datos limitados sobre la vitamina B12, la homocisteína y la salud cognitiva/cerebral en la India rural.

Objetivo del estudio:

  • Evaluar la asociación entre la vitamina B12 sérica, la homocisteína, los volúmenes cerebrales por RM y el rendimiento cognitivo en una población rural envejecida de la India.
  • Investigar los posibles efectos mediadores de la homocisteína entre la vitamina B12 y los resultados cognitivos/cerebrales.

Principales métodos:

  • Análisis transversal de 2784 participantes no demenciados (mayores de 45 años) de la cohorte CBR-SANSCOG.
  • Evaluación cognitiva utilizando la batería HMSE y COGNITO; volumetría cerebral por RM en un subconjunto (n=1268).
  • Análisis estadístico utilizando modelos lineales generales, ajustando por múltiples covariables.

Principales resultados:

  • No se encontró asociación entre los niveles de vitamina B12 y el rendimiento cognitivo o los volúmenes cerebrales.
  • Los niveles elevados de homocisteína se correlacionaron con puntuaciones más bajas en HMSE y atención visual, y con una reducción del volumen del hipocampo.
  • La homocisteína no medió la relación entre la vitamina B12 y los resultados cognitivos/cerebrales.

Conclusiones:

  • El aumento de la homocisteína sérica se asocia negativamente con el rendimiento cognitivo en esta población, independientemente de los niveles de vitamina B12.
  • El cribado temprano de homocisteína puede identificar a las personas en riesgo de deterioro cognitivo.
  • La homocisteína podría ser un componente de un biomarcador multimodal para la detección temprana del deterioro cognitivo.