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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

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Manifestaciones Clínicas

Molly Split1,2,3, Daliah Ross2,3, Zachary J Kunicki1,2,3

  • 1Alpert Medical School of Brown University, Providence, RI, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La memoria y los síntomas conductuales como la irritabilidad predicen una progresión más rápida en la demencia frontotemporal de predominio frontotemporal (DFTF). La identificación de estos indicadores clave puede guiar intervenciones tempranas para pacientes con DFTF.

Palabras clave:
demencia frontotemporal de predominio frontotemporalprogresión de la enfermedadmemoria de trabajocomportamientos compulsivosirritabilidadintervención temprana

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Área de la Ciencia:

  • Neurociencia
  • Neurología
  • Investigación Clínica

Sus antecedentes:

  • La demencia frontotemporal de predominio frontotemporal (DFTF) es un trastorno neurodegenerativo progresivo caracterizado por cambios conductuales y de las funciones ejecutivas.
  • Predecir la progresión de la DFTF es un desafío debido a su naturaleza heterogénea.
  • Si bien la edad y la genética son factores conocidos, el impacto de síntomas específicos en la progresión es menos comprendido.

Objetivo del estudio:

  • Identificar síntomas neuropsiquiátricos, motores y cognitivos específicos asociados con la progresión rápida de la DFTF durante un año.
  • Determinar qué síntomas son más predictivos del avance rápido de la enfermedad.

Principales métodos:

  • Se utilizaron datos de 192 participantes con DFTF del estudio ARTFL-LEFFTDS, clasificándolos como progresores rápidos o lentos.
  • Se empleó el modelado de bosque aleatorio para identificar los síntomas predictivos clave de una lista de 43 características.
  • Se evaluó el rendimiento del modelo utilizando AUC, sensibilidad, especificidad y otras métricas, y se utilizó la regresión logística para evaluar el valor predictivo incremental.

Principales resultados:

  • Las 5 características predictivas principales para la progresión rápida de la DFTF incluyeron deterioro de la memoria verbal y de trabajo, comportamientos compulsivos, irritabilidad y deterioro de la flexibilidad mental.
  • Un modelo que utiliza estas 5 características logró un AUC de 0.75, lo que demuestra un poder predictivo significativo.
  • La adición de estos síntomas clave a variables demográficas y clínicas mejoró sustancialmente la predicción de progresión rápida.

Conclusiones:

  • El deterioro de la memoria (verbal y de trabajo), los comportamientos compulsivos y la irritabilidad son indicadores fuertes de una progresión más rápida de la DFTF.
  • Estos síntomas son más efectivos que los factores demográficos por sí solos para distinguir el avance rápido frente al lento de la enfermedad.
  • Estos hallazgos pueden informar intervenciones tempranas específicas, educación familiar y estrategias de manejo para pacientes con DFTF.