Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Rhabdomyolysis-Induced Resistant Hypercalcemia During the Recovery Phase of Acute Kidney Injury.

Cureus·2026
Same author

Planar Pentacoordinate Nitrogen with Activated N─N Bond.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026
Same author

The Prevalence of Co-Occurring Conditions and an Exploration of Social Factors Influencing Health in Down Syndrome.

American journal of medical genetics. Part A·2026
Same author

Down Syndrome Births Among Live Births from the CDC Wonder Database.

Children (Basel, Switzerland)·2026
Same author

Electronic Structure of All-Metal Neutral M<sub>4</sub> (M = Al, Ga, In) Rings: Aromaticity and Spin-Avoided σ-σ Diradical Character.

The journal of physical chemistry. A·2026
Same author

Theoretical Prediction of Strong Be-B and Be-Al Bonds in [FBeER<sub>3</sub>]<sup>-</sup> (E = B, Al; R = H, CH<sub>3</sub>, Ph) Adducts: Dative or Covalent Bonding?

Inorganic chemistry·2026
Same journal

Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Plasma-based neurobiological protein biomarkers as predictors of dementia progression: Insights from longitudinal aging study in India - Diagnostic assessment of dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Neuropathology-specific language features in primary progressive aphasia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Dementia blood biomarkers in the context of post-stroke cognitive outcomes: Systematic review and evidence synthesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Ver todos los artículos relacionados
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Manifestaciones Clínicas

Amit Das1, Matthew P Janicki2,3, Natalia S Rozas1

  • 1LuMind IDSC Foundation, Woburn, MA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Las herramientas especializadas son cruciales para diagnosticar la enfermedad de Alzheimer en personas con síndrome de Down (EA-SD), ya que los métodos estándar son ineficaces, especialmente para aquellos con discapacidad intelectual (DI) de moderada a grave. Se recomiendan las evaluaciones basadas en informantes para todos los niveles de DI.

Palabras clave:
Síndrome de DownEnfermedad de AlzheimerDiscapacidad IntelectualEvaluación CognitivaHerramientas de Diagnóstico

Más Videos Relacionados

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from S&#233;zary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Videos de Experimentos Relacionados

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from S&#233;zary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Área de la Ciencia:

  • Gerontología y Enfermedades Neurodegenerativas
  • Genética y Discapacidades del Desarrollo
  • Evaluación Clínica y Diagnóstico

Sus antecedentes:

  • Las personas con síndrome de Down (SD) enfrentan un riesgo sustancialmente elevado de padecer la enfermedad de Alzheimer (EA) en comparación con la población neurotípica (NT).
  • La discapacidad intelectual (DI) inherente en el SD requiere herramientas de evaluación especializadas para detectar el deterioro cognitivo en la EA asociada al SD (EA-SD).

Objetivo del estudio:

  • Investigar las perspectivas internacionales sobre la utilidad y aplicación de las herramientas de evaluación para la EA-SD.
  • Evaluar la efectividad de las herramientas de evaluación existentes para la EA-SD en diferentes niveles de discapacidad intelectual.

Principales métodos:

  • Se distribuyó una encuesta a 51[...]
  • El análisis incluyó 43[...]
  • La encuesta consultó sobre la estadificación clínica del deterioro cognitivo leve en el SD (MCI-SD) y la demencia por EA-SD.

Principales resultados:

  • Más del 95% de los encuestados estuvo de acuerdo en que las herramientas de EA diseñadas para personas neurotípicas (NT) no son adecuadas para detectar MCI-DS y Demencia por EA-SD, particularmente en personas con DI de moderada a grave.
  • Las evaluaciones basadas en informantes fueron altamente calificadas por su utilidad y adecuación en todos los niveles de gravedad de DI (leve a profunda).
  • Las evaluaciones directas se consideraron de gran utilidad principalmente para la DI de leve a moderada, con calificaciones de adecuación significativamente menores para la DI grave y profunda.

Conclusiones:

  • Existe un fuerte consenso sobre la utilidad limitada de las herramientas de EA diseñadas para NT en el diagnóstico de EA-SD, lo que resalta la necesidad crítica de herramientas especializadas para el SD.
  • Se recomiendan las herramientas basadas en informantes por su mayor aplicabilidad en todo el espectro de la DI, mientras que las evaluaciones directas son más adecuadas para la DI leve.
  • Las variaciones regionales en el conocimiento de las herramientas subrayan la necesidad de un marco global para estandarizar la evaluación de la EA-SD y garantizar una atención basada en la evidencia.