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Manifestaciones Clínicas

Federica Cacciamani1,2, Graziella Mangin Laignel1, Audrey Gabelle3,4

  • 1Qairnel, Paris, France, France.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Las personas referidas por informantes con deterioro cognitivo subjetivo muestran perfiles de mayor riesgo de enfermedad de Alzheimer. Esto resalta la importancia de los informes de los informantes para identificar a aquellos que necesitan intervención y apoyo tempranos.

Palabras clave:
deterioro cognitivo subjetivoenfermedad de Alzheimerinformantesintervención tempranaperfil de riesgo

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Área de la Ciencia:

  • Gerontología
  • Neurología
  • Ciencias Cognitivas

Sus antecedentes:

  • El deterioro cognitivo subjetivo (SCD, por sus siglas en inglés) es una preocupación común en adultos mayores, a menudo reportada por el individuo o un informante.
  • El SCD reportado por informantes puede indicar un mayor riesgo de enfermedad de Alzheimer y trastornos relacionados (ADRD).
  • DocMemo es una plataforma digital que ofrece detección cognitiva y recursos para personas con preocupaciones cognitivas y sus informantes.

Objetivo del estudio:

  • Comparar individuos referidos por sí mismos e informantes en la plataforma DocMemo.
  • Investigar la asociación entre el tipo de derivación y los factores de riesgo de demencia establecidos.

Principales métodos:

  • Los usuarios se clasificaron como referidos por sí mismos o por informantes según un cuestionario de quejas cognitivas.
  • La regresión logística multivariante analizó la asociación entre el tipo de derivación y diversos factores demográficos, cognitivos, psicológicos, de salud y de estilo de vida.
  • Los análisis se ajustaron para comparaciones múltiples.

Principales resultados:

  • Los usuarios referidos por informantes (2554) tuvieron más quejas cognitivas y eran mayores que los usuarios referidos por sí mismos (10489).
  • Los factores asociados con la derivación por informantes incluyeron mayores quejas cognitivas, mayor edad y ansiedad.
  • Los factores asociados con la autoderivación incluyeron ser mujer, mayor nivel educativo, trastornos del sueño, tabaquismo y disposición a participar en la investigación.

Conclusiones:

  • Los usuarios referidos por informantes presentan perfiles de mayor riesgo de enfermedad de Alzheimer, en consonancia con los factores de riesgo de demencia modificables.
  • Los informes de los informantes son valiosos para identificar a las personas con mayor riesgo, lo que sugiere una población vulnerable.
  • Reconocer estas diferencias es clave para optimizar la detección y brindar apoyo oportuno a las personas en riesgo.