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Manifestaciones Clínicas

Meaghan Am McKenna1, Charlotte B Curnin1, John Torous1

  • 1Beth Israel Deaconess Medical Center, Boston, MA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Una nueva prueba cognitiva en línea, D-Cog, muestra ser prometedora para la monitorización de la enfermedad de Alzheimer en el hogar. Esta herramienta puede detectar cambios cognitivos, ayudando al diagnóstico temprano de afecciones como el delirio o la ARIA.

Palabras clave:
Enfermedad de AlzheimerD-CogMonitorización cognitivaSalud digitalPruebas neuropsicológicas

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Área de la Ciencia:

  • Neurología
  • Gerontología
  • Salud Digital

Sus antecedentes:

  • Los pacientes con enfermedad de Alzheimer (EA) en etapa temprana experimentan fluctuaciones cognitivas.
  • Los cambios pueden indicar afecciones graves como delirio o ARIA por terapia reductora de amiloide.
  • Las herramientas actuales carecen de capacidades de evaluación cognitiva frecuente en el hogar.

Objetivo del estudio:

  • Investigar la utilidad, conveniencia y viabilidad de una nueva evaluación cognitiva en línea (D-Cog) para uso en el hogar.
  • Evaluar el potencial de D-Cog para detectar cambios cognitivos en pacientes con EA.
  • Evaluar D-Cog como herramienta para la detección temprana de delirio o ARIA.

Principales métodos:

  • Se desarrolló D-Cog, una breve prueba cognitiva en línea (<2 min) diseñada como un "signo vital cognitivo".
  • Se recopilaron datos piloto de 82 pacientes con MCI o EA.
  • Se reclutaron 15 participantes para una evaluación diaria de D-Cog en el hogar durante 6 meses con monitorización remota.

Principales resultados:

  • 54 participantes (edad media 76) completaron el estudio, con una puntuación media de D-Cog de 3,9.
  • Las puntuaciones de D-Cog se correlacionaron significativamente con las puntuaciones del Mini-Examen del Estado Mental (MMSE) (r=0,56, p=1,3e-5).
  • Los pacientes informaron que D-Cog era fácil de completar en casa.

Conclusiones:

  • La evaluación D-Cog es factible para la práctica clínica y el uso remoto en el hogar por parte de pacientes con EA.
  • Las puntuaciones de D-Cog muestran una buena correlación con las pruebas neuropsicológicas tradicionales.
  • D-Cog muestra ser prometedor para la monitorización frecuente y conveniente en el hogar y la detección temprana de cambios cognitivos.