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Manifestaciones Clínicas

Kristin Harkins1, Jason Karlawish1, Kyra O'Brien1

  • 1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los médicos que revelaron los resultados de la tomografía por emisión de positrones (PET) de amiloide de la enfermedad de Alzheimer (EA) en ADNI-4 informaron alta confianza y una comprensión adecuada de los participantes. El estudio destaca las prácticas de divulgación efectivas para la investigación futura y la atención clínica.

Palabras clave:
Enfermedad de AlzheimerPET de amiloideDivulgación de biomarcadoresExperiencia del médicoComprensión del paciente

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Área de la Ciencia:

  • Neurología; Neuroimagen; Divulgación de biomarcadores

Sus antecedentes:

  • Investigaciones anteriores se centraron en las experiencias de los pacientes con la divulgación de biomarcadores de la enfermedad de Alzheimer (EA).
  • Las experiencias de los médicos que divulgan biomarcadores de la EA siguen estando poco caracterizadas.

Objetivo del estudio:

  • Examinar la experiencia del médico al divulgar los resultados de la tomografía por emisión de positrones (PET) de amiloide.
  • Informar las futuras prácticas de divulgación en la investigación y atención de la EA.

Principales métodos:

  • El estudio involucró a médicos que divulgaron resultados de PET de amiloide en el estudio de cohortes longitudinales ADNI-4.
  • Los médicos que divulgaron completaron cuestionarios posteriores a la divulgación, informando sobre la duración de la visita, la comprensión, las reacciones emocionales, los temas, los desafíos y la evaluación general.

Principales resultados:

  • Los médicos informaron una alta confianza (70-77%) en el manejo de la divulgación y la respuesta a preguntas.
  • La comprensión de los participantes y sus compañeros de estudio se calificó como adecuada en la mayoría de los casos (94% para los participantes).
  • Las visitas de divulgación promediaron 29.4 minutos, y las discusiones se centraron en el significado del resultado (99%) y el impacto emocional (49%).

Conclusiones:

  • Los médicos en el estudio ADNI-4 expresaron alta confianza y percibieron una comprensión adecuada entre los participantes y los compañeros de estudio.
  • Los desafíos durante la divulgación fueron infrecuentes, y la mayoría de las visitas se calificaron como buenas o excelentes.
  • Estos hallazgos, combinados con los datos de los participantes, guiarán la futura divulgación de resultados de PET de amiloide en entornos de investigación y clínicos.