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Ensamblaje de F-actina nuclear regulado por pH durante la ferroptosis
Menghao Qiao1, Zhipeng Yan1, Jiewei Huang1
1Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Department of Developmental and Regenerative Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Frontiers in cell and developmental biology
|December 26, 2025
Resumen
El ensamblaje de actina nuclear ocurre durante la ferroptosis, impulsado por la acidificación intracelular y la importación nuclear. Este proceso es una consecuencia, no una causa, de la muerte celular.
Área de la Ciencia:
- Biología Celular; Bioquímica
Sus antecedentes:
- La ferroptosis es una vía de muerte celular dependiente del hierro.
Objetivo del estudio:
- Investigar el comportamiento de la actina filamentosa (F-actina) nuclear durante la ferroptosis.
Principales métodos:
- Tratamiento con RSL3 para inducir ferroptosis en células HT-1080.
Principales resultados:
- Se ensambló F-actina nuclear durante la ferroptosis inducida por RSL3.
- Aumentó la G-actina nuclear y la reducción de IPO9 disminuyó la F-actina nuclear, lo que sugiere dependencia de la importación.
- La acidificación intracelular promovió el ensamblaje de F-actina nuclear, mientras que las condiciones alcalinas extracelulares lo suprimieron.
Conclusiones:
- El ensamblaje de F-actina nuclear durante la ferroptosis está impulsado por la remodelación de la actina citoplasmática, la importación nuclear y la acidificación intracelular.
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