Video Experimental Relacionado

Updated: Jan 7, 2026

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Ossificación heterotópica en una lesión serrada sésil apendicular con tumor neuroendocrino sincrónico

Paul J Wurtz¹, Douglas Walton², Calen Gist³

¹Department of Internal Medicine, Brooke Army Medical Center, San Antonio, TX.

ACG case reports journal

|December 26, 2025

Abstract:

Heterotopic ossification (HO) in colorectal polyps is rare and scarcely reported in serrated lesions. We report an appendiceal sessile serrated lesion (SSL) with mature bone and a contiguous well-differentiated neuroendocrine tumor. A 64-year-old woman had a firm appendiceal-orifice polyp biopsied in 2012 showing calcification; SSL was identified in 2019. In 2024, an 8-mm lesion was removed en bloc by underwater cold snare; histology showed SSL with HO. Laparoscopic appendectomy confirmed residual SSL with HO and an adjacent 4.5-mm grade-1 neuroendocrine tumor (INSM1+, Ki-67 <3%) with negative margins. HO recognition should prompt en bloc excision and attentive pathology.

Palabras clave:

orificio apendicular pólipo colorrectal osificación heterotópica tumor neuroendocrino metaplasia ósea lesión serrada sésil cinta fría subacuática

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