Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Impact of left vs. right hemisphere stroke on driving: lateralized attention deficits and executive dysfunction linked to impaired driving.

Frontiers in stroke·2026
Same author

A randomized controlled trial of online mindfulness-based stress reduction in chronic stroke.

Rehabilitation psychology·2026
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Diminished preparatory physiological responses in people with dementia: associations with caregiver health and relationship quality.

The journals of gerontology. Series B, Psychological sciences and social sciences·2025
Same author

Interpersonal Physiological Linkage Between People With Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease and Their Informal Caregivers.

Psychophysiology·2025
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Manifestaciones Clínicas

Timothy J Herron1, Jas M Chok1,2, Sandy J Lwi1

  • 1Veterans Affairs Northern California Health Care System, Martinez, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Factores cognitivos novedosos de la California Cognitive Assessment Battery (CCAB) se correlacionan con quejas de memoria subjetivas en adultos mayores sanos. Estos factores pueden servir como marcadores tempranos de deterioro cognitivo.

Palabras clave:
deterioro cognitivomarcadores cognitivosadultos mayoresquejas subjetivasfactores cognitivos

Más Videos Relacionados

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Videos de Experimentos Relacionados

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Área de la Ciencia:

  • Neurociencia
  • Gerontología
  • Psicología Cognitiva

Sus antecedentes:

  • Los avances en el tratamiento de la demencia exigen marcadores sensibles para el deterioro cognitivo temprano.
  • La identificación del deterioro cognitivo temprano en adultos mayores sanos es crucial.
  • Las quejas cognitivas subjetivas son un indicador potencial de deterioro temprano.

Objetivo del estudio:

  • Evaluar la utilidad de las métricas de pruebas cognitivas primarias y secundarias de una batería computarizada para identificar el deterioro cognitivo temprano.
  • Explorar la relación entre los factores cognitivos novedosos y las quejas cognitivas subjetivas.
  • Evaluar marcadores cognitivos en un estudio longitudinal de participantes mayores cognitivamente sanos.

Principales métodos:

  • Se evaluó a 309 adultos mayores cognitivamente sanos utilizando la California Cognitive Assessment Battery (CCAB) durante 30 meses.
  • Se derivaron factores agregados tradicionales y factores cognitivos novedosos (incluidas métricas secundarias) de las puntuaciones de la CCAB.
  • Se utilizaron modelos mixtos lineales (LMM) y modelos mixtos de clases latentes (LCMM) para analizar datos longitudinales y comparar factores cognitivos con quejas de memoria subjetivas (Cognitive Failures Questionnaire - CFQ).

Principales resultados:

  • Factores novedosos (Memoria, Visuoespacial/Ejecutivo, Velocidad Incidental) y un factor tradicional PACC-R se correlacionaron significativamente con subpuntuaciones elevadas del CFQ.
  • No se encontraron interacciones significativas entre el CFQ elevado y la disminución del aprendizaje de pruebas o de factores a lo largo de 30 meses.
  • Los análisis LCMM arrojaron resultados mixtos; un método clasificó a los sujetos por vocabulario, edad y raza, con una débil correlación con el CFQ.

Conclusiones:

  • Los factores cognitivos novedosos derivados de la CCAB se asocian con quejas cognitivas subjetivas como el olvido.
  • Estos marcadores cognitivos novedosos muestran potencial como indicadores tempranos de deterioro cognitivo.
  • Se está realizando una validación adicional en poblaciones diversas y entornos clínicos (por ejemplo, Deterioro Cognitivo Leve).