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Manifestaciones Clínicas

Kristen E Kehl-Floberg1, Aurora Pop-Vicas1, Dorothy F Edwards2,3

  • 1University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La función cognitiva autoinformada, medida por las puntuaciones de la función cognitiva de PROMIS, predice significativamente la COVID prolongada. Las puntuaciones bajas se asociaron con una probabilidad de cinco a seis veces mayor de experimentar síntomas de COVID prolongada.

Palabras clave:
COVID prolongadafunción cognitivaPROMISMoCAevaluación neurocognitivasalud públicaenfermedades infecciosasneurociencia

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Área de la Ciencia:

  • Neurociencia
  • Salud Pública
  • Enfermedades Infecciosas

Sus antecedentes:

  • La COVID prolongada se caracteriza por síntomas neurocognitivos debilitantes, a menudo denominados 'niebla cerebral'.
  • Las herramientas de detección neurocognitiva existentes detectan de manera inadecuada los déficits cognitivos post-COVID.
  • La detección eficaz de la disfunción cognitiva en pacientes con COVID prolongada es crucial para el manejo clínico.

Objetivo del estudio:

  • Comparar la asociación de la función cognitiva autoinformada con las pruebas neuropsicológicas con el estado de COVID prolongada.
  • Identificar métodos de detección fiables para el deterioro cognitivo en personas con síntomas persistentes post-COVID.

Principales métodos:

  • Un estudio de cohorte transversal analizó 174 participantes (67 casos, 107 controles) con COVID prolongada.
  • La regresión logística binaria modeló el estado de COVID prolongada utilizando puntuaciones MoCA (Montreal Cognitive Assessment) y puntuaciones t de la Escala de Funcionamiento Cognitivo PROMIS (Patient-Reported Outcomes Measurement Information System) de 8 ítems.
  • Los análisis controlaron la edad e incorporaron la ponderación por raza/etnia para las puntuaciones de corte de MoCA.

Principales resultados:

  • Las puntuaciones bajas de la función cognitiva de PROMIS (cuartil inferior de 36,67) aumentaron significativamente las probabilidades de tener COVID prolongada entre cinco y siete veces en varios grupos de edad, incluso con una puntuación MoCA 'No alterada'.
  • Los recortes de puntuación MoCA ponderados por raza/etnia no predijeron significativamente el estado de COVID prolongada a ninguna edad.
  • Las puntuaciones de la función cognitiva de PROMIS demostraron una asociación robusta con la COVID prolongada, independiente de la edad y el rendimiento de MoCA.

Conclusiones:

  • Las puntuaciones de la función cognitiva de PROMIS autoinformadas son predictores sólidos de la COVID prolongada.
  • Estas puntuaciones autoevaluadas son más eficaces que las evaluaciones MoCA tradicionales para identificar la disfunción cognitiva relacionada con la COVID prolongada.
  • La función cognitiva de PROMIS ofrece una herramienta sensible para la detección y evaluación de los impactos cognitivos de las condiciones post-COVID.