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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Heart Failure III: Clinical Manifestations01:26

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

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Manifestaciones Clínicas

Yara Alkhodair1,2, Imogene M Scott1, Abdulrahman Alzahrani1

  • 1Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
Resumen
Este resumen es generado por máquina.

El cambio neuropatológico de encefalopatía relacionada con la edad predominante en el límbico (LATE-NC) no aumentó los síntomas neuropsiquiátricos generales en personas con enfermedad de Alzheimer y/o enfermedad de cuerpos de Lewy. Las alucinaciones fueron menos frecuentes en el grupo LATE-NC.

Palabras clave:
Enfermedad de AlzheimerEnfermedad de cuerpos de LewyLATE-NCSíntomas neuropsiquiátricosPatología TDP-43

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Área de la Ciencia:

  • Neuropatología
  • Neuropsiquiatría
  • Medicina Geriátrica

Sus antecedentes:

  • El cambio neuropatológico de encefalopatía relacionada con la edad predominante en el límbico (LATE-NC) a menudo coexiste con la enfermedad de Alzheimer (AD), la enfermedad de cuerpos de Lewy (LBD) y la patología vascular.
  • Si bien los síntomas neuropsiquiátricos en AD/LATE-NC se estudian cada vez más, su impacto en LBD mixta y LBD sigue sin explorarse.

Objetivo del estudio:

  • Investigar y comparar los perfiles de síntomas neuropsiquiátricos en individuos con AD, LBD y AD/LBD mixta, con y sin LATE-NC.
  • Analizar la influencia de LATE-NC en la gravedad y progresión de los síntomas neuropsiquiátricos en estos grupos de pacientes.

Principales métodos:

  • Estudio de cohorte retrospectivo de casos confirmados por autopsia de la base de datos UBCH-CARD.
  • Emparejamiento de 42 casos positivos para LATE-NC (LATE+) con 38 casos negativos para LATE-NC (LATE-) basándose en la edad y la neuropatología.
  • Evaluación de los síntomas neuropsiquiátricos utilizando el Cuestionario de Inventario Neuropsiquiátrico (NPI-Q) y análisis de datos longitudinales utilizando modelos lineales de efectos mixtos.

Principales resultados:

  • No se encontraron diferencias significativas en la gravedad general de los síntomas neuropsiquiátricos o en la carga longitudinal entre los grupos LATE+ y LATE-.
  • La apatía, las alucinaciones y los cambios en el apetito fueron menos graves en el grupo LATE+.
  • Las alucinaciones siguieron siendo significativamente menos frecuentes en el grupo LATE+ incluso después de ajustar por patologías coexistentes.

Conclusiones:

  • LATE-NC no parece exacerbar la carga general de síntomas neuropsiquiátricos en individuos con AD y/o LBD.
  • La menor frecuencia de alucinaciones en el grupo LATE+ justifica una mayor investigación, potencialmente relacionada con la patología de cuerpos de Lewy.
  • El modelado longitudinal de la progresión de los síntomas requiere un análisis adicional para comprender completamente el impacto de LATE-NC.