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Evidencia de que la interleucina-17C gobierna la patogenicidad de la interleucina-17A y promueve el cambio de
Yu-Wei Zhang1,2,3, Yu-Hua Wen3, Ling Yang3
1Department of Respiratory and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Nature communications
|December 26, 2025
Resumen
La interleucina-17C (IL-17C) impulsa la IL-17A en la superposición de bronquiectasia y asma (BAO), promoviendo el asma neutrofílica. La IL-17C puede ofrecer una nueva estrategia terapéutica para pacientes con BAO.
Área de la Ciencia:
- Inmunología
- Medicina Respiratoria
- Fisiopatología
Sus antecedentes:
- La superposición de bronquiectasia y asma (BAO) presenta desafíos de manejo.
- Los fenotipos específicos que impulsan la BAO siguen siendo poco comprendidos.
- La participación de la vía de la interleucina-17 (IL-17) en las enfermedades respiratorias se reconoce cada vez más.
Objetivo del estudio:
- Investigar el papel de IL-17C en la fisiopatología de BAO.
- Explorar la relación entre IL-17C, IL-17A y las células linfoides innatas del grupo 3 (ILC3) en pacientes con BAO.
- Elucidar los mecanismos por los cuales IL-17C influye en el cambio de fenotipo del asma en el contexto de la bronquiectasia.
Principales métodos:
- Reclutamiento de pacientes con bronquiectasia y asma coexistente.
- Análisis de muestras de sangre periférica para niveles de IL-17C, IL-17A e ILC3.
- Desarrollo y utilización de un modelo de ratón que involucra infección por Pseudomonas aeruginosa y asma inducida por ovoalbúmina.
Principales resultados:
- Correlación positiva entre los niveles de IL-17C e IL-17A/ILC3 en pacientes con BAO.
- IL-17C mejora la expresión de IL-17A en ILC3s a través del receptor IL-17 E en un modelo de ratón.
- La ablación de Il17re en ratones redujo las respuestas de ILC3 y mitigó el cambio de fenotipo del asma impulsado por IL-17A.
- La disfunción de la barrera epitelial inducida por Pseudomonas aeruginosa se correlacionó con un aumento de la producción de IL-17C.
Conclusiones:
- IL-17C juega un papel crítico en la regulación de la patogenicidad de IL-17A en BAO.
- IL-17C promueve el cambio de fenotipo del asma hacia fenotipos neutrofílicos en la bronquiectasia.
- IL-17C emerge como un objetivo terapéutico potencial para el manejo de BAO.
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