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Updated: Jan 7, 2026
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Gradientes periventriculares en la microestructura axonal y de mielina presentes en personas con esclerosis múltiple
Hannah R Bernstein1,2,3, Vladimir Grouza1,2, Joseph S Gati4
1McConnell Brain Imaging Centre, The Neuro (Montreal Neurological Institute-Hospital), Montreal, QC, Canada.
Background:
MS imaging studies have demonstrated an ependymal "surface-in" distribution of white matter damage. The origin of this effect and how it impacts myelinated axons in people with MS (PwMS) is poorly understood.
Objectives:
To investigate (1) whether there is clear evidence of tract-wise, periventricular damage, based on fractional anisotropy, mean diffusivity, axonal water fraction (AWF) and myelin volume fraction (MVF), in PwMS, (2) if such tissue damage is associated with T1-"black-hole" (T1-BH) and/or non-BH lesions, and (3) if periventricular quantitative MRI abnormalities are correlated with lateral ventricle (LV) and choroid plexus (CP) enlargement.
Methods:
We applied structural, MT-weighted, and multi-shell diffusion MRI in healthy controls and PwMS to quantify periventricular gradient damage to axons and myelin. We also evaluated the correlation between such gradient damage and both non-BH and T1-BH lesion loads, and brain volume changes.
Results:
Clear periventricular gradients exist in both AWF and MVF measures in the Association and Projection Tracts. They are strongly correlated with T1-BH lesion load, and with LV and CP enlargement in PwMS with EDSS > 2.
Conclusions:
Tract-specific, periventricular gradients in PwMS exist prominently in AWF and MVF, are strongly associated with T1-BH lesion loads, and correlate with LV and CP enlargement.
