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Ingeniería de la secreción de IL-21 en células T mediante dominios estabilizados por ligandos y susceptibles a

Dong Hyun Kim1, Seo Jin Lee1,2, Taeyoung Ahn1

  • 1Laboratory of Cell & Gene Therapy, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.

Scientific reports
|December 27, 2025
PubMed
Resumen

Los investigadores diseñaron un sistema controlable de administración de Interleucina-21 (IL-21) para una inmunoterapia más segura. Este método regula con precisión la liberación de citoquinas, mejorando la persistencia de las células T para la terapia celular adoptiva.

Palabras clave:
dominio de desestabilización (DD)IL-21InmunoterapiaRegulación dependiente de ligandosIngeniería de células T

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