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Updated: Jan 7, 2026

Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data

Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data

Published on: May 15, 2019

HUBMet: una base de datos integradora y plataforma analítica para metabolitos de la sangre humana y asociaciones de

Xingyue Wang^1,2, Xiangyu Qiao^1,2, Alberto Zenere^1,2

¹Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SE-581 83, Sweden.

|December 27, 2025

Abstract:

Understanding human blood metabolites is essential for deciphering systemic physiology and disease mechanisms, yet remains challenging due to diverse origins and dynamic regulation. In this study, we develop HUBMet (https://hubmet.app.bio-it.tech/home), an open-access web server that includes 3,950 metabolites and 129,814 metabolite-protein associations, with four analytical modules: Over-Representation Analysis (ORA) for enrichment analysis; Metabolite Set Enrichment Analysis (MSEA) for quantitative data analysis; Tissue Specificity Analysis (TSA) for assessing metabolite-tissue relevance; Metabolite-Protein Network Analysis (MPNet) for identifying key metabolite-protein associations and functional modules. HUBMet's utility is demonstrated through a COVID-19 case study revealing metabolic signatures associated with disease severity.

Palabras clave:

Análisis de enriquecimiento Metabolito de la sangre humana Análisis de conjuntos de metabolitos Asociaciones de metabolitos-proteínas Análisis de redes Especificidad tisular

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