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Producción de DPO por comensales intestinales sugiere un papel más amplio en la comunicación bacteriana e

Michael Moraskie¹, Sara Li¹, Josep-Ramon Codina¹

¹Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA.

NPJ biofilms and microbiomes

|December 28, 2025

Abstract:

The quorum-sensing molecule 3,5-dimethylpyrazine-2-ol (DPO), known for regulating biofilm formation in Vibrio cholerae, has unknown distribution among commensal bacteria. We screened 37 bacterial strains using a validated biosensor and found widespread production. Inoculating mice with high producers elevated gut DPO levels, highlighting DPO's potential influence on gut microbiota. These findings expand DPO's ecological relevance and underscore quorum sensing as a potentially critical influence on microbiome function and host-microbe interactions.

Palabras clave:

comunicación bacteriana interacciones huésped-microbioma microbioma intestinal detección de quórum DPO comensales intestinales

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