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La plataforma NewroBus: nanobodies humanizados de ingeniería anti-TfR1 para una entrega cerebral eficiente
Tao Yin1, Metin Yesiltepe1, Sanjay Metkar1
1Department of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Jacqueline Krieger Klein Center in Alzheimer's Disease and Neurodegeneration Research, The State University of New Jersey, 205 South Orange Ave, RutgersNewark, NJ, 07103, USA.
Nuevos nanobodies (NewroBus) entregan eficientemente biológicos a través de la barrera hematoencefálica (BHE) a través del receptor de transferrina 1 (TfR1). Esta plataforma preserva el transporte de hierro y ofrece un método seguro y versátil para la administración de fármacos en el sistema nervioso central (SNC).
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