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Niveles de hormona tiroidea en adultos en la India: Un estudio transversal
Hemraj1, Varun Gupta1, Mudassar Ahmed Shariff2
1Department of General Medicine, FH Medical College and Hospital, Agra, Uttar Pradesh, India.
Bioinformation
|December 30, 2025
Resumen
Los niveles de hormona tiroidea, incluida la hormona estimulante de la tiroides (TSH), la tiroxina libre (FT4) y la triyodotironina libre (FT3), varían según la edad y el sexo en adultos indios. Este estudio establece rangos de referencia específicos por edad y sexo para estas pruebas de función tiroidea.
Área de la Ciencia:
- Endocrinología
- Tiroidología
- Bioquímica Clínica
Sus antecedentes:
- La fisiología tiroidea está influenciada por la edad y el sexo.
- Los rangos de referencia específicos de la India para las pruebas de función tiroidea (TFT) no están bien definidos.
- La interpretación precisa de las TFT requiere datos estratificados por edad y sexo.
Objetivo del estudio:
- Determinar los límites de referencia específicos por edad y sexo para TSH, FT4 y FT3 en la población india.
- Establecer rangos de referencia actualizados para las pruebas de función tiroidea en adultos indios eutiroideos.
- Proporcionar datos para una mejor interpretación de las TFT en la India.
Principales métodos:
- Un estudio transversal multicéntrico basado en la comunidad.
- Inclusión de 5.812 adultos eutiroideos de cinco regiones de la India.
- Análisis de muestras en ayunas de la mañana utilizando plataformas quimioluminiscentes estandarizadas y métodos de percentiles no paramétricos.
Principales resultados:
- La TSH media fue mayor en mujeres que en hombres y aumentó con la edad.
- Los niveles de FT4 y FT3 mostraron una leve disminución con el aumento de la edad.
- El percentil 97,5 para la TSH aumentó con la edad, observándose límites superiores más altos en mujeres en todos los grupos de edad.
Conclusiones:
- La edad y el sexo impactan significativamente los resultados de las pruebas de función tiroidea en adultos indios.
- Los rangos de referencia específicos por edad y sexo establecidos son cruciales para la interpretación precisa de las TFT.
- Este estudio proporciona datos esenciales para optimizar el diagnóstico de trastornos tiroideos en la India.
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