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Regulación Dual de Hormonas para el Control de la Glucosa en Sangre Mediante Microesferas Janus a Base de

Yixin Cai¹, Wenxuan Xu¹, Kangrui Yuan¹

¹National Key Laboratory for the Development and Utilization of Forest Food Resources, Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China.

Journal of agricultural and food chemistry

|December 30, 2025

Abstract:

Pancreatic α and β cells secrete glucagon and insulin, respectively, and regulate blood glucose through feedback mechanisms. To fully simulate the functions of pancreatic α and β cells within the same microsphere, cellulose/chitosan-based Janus microspheres (JMs) were created using the gas-shearing microfluidics, allowing for precise blood glucose regulation through coordinated dual-hormone release. One compartment of the JMs is primarily made up of carboxymethyl cellulose and glucagon. The dissociation of hydrogen bonds in the cellulose hydroxyl network causes swelling and releases glucagon when pH > 7.4. The other compartments of the JMs primarily consist of chitosan, insulin, and glucose oxidase (GOD). GOD reacts with glucose to produce gluconic acid (3.77 < pH < 6.86), which protonates the amino groups on chitosan, releasing insulin. In coculture experiment, JMs maintained blood glucose within the normal range within 1-2 h without showing hypoglycemic symptoms, with microspheres sustaining normal blood glucose levels for approximately 10-11 h.

Palabras clave:

microesferas Janus celulosa quitosano glucagón insulina

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