Video Experimental Relacionado

Updated: Jan 7, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Restricción del crecimiento fetal asociada con cambios estructurales en el lóbulo frontal en lactantes prematuros de

Jose Uberos¹, Marta Carrasco-Solis², Carolina Laynez-Rubio³

¹Department of Pediatrics, School of Medecine, Granada University, Spain; Neonatal Intensive Care Unit, San Cecilio Clinical Hospital. Medicine Faculty, Granada, Spain; Instituto de Investigación Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, Spain.

Pediatrics and neonatology

|December 30, 2025

Abstracto

Aims:

To analyze the development of the frontal cortical and subcortical areas in children with a history of prematurity and very low birthweight, and to evaluate its relationship with foetal growth restriction (FGR) and birthweight.

Methods:

This cohort study was carried out in two stages: retrospectively, considering very low weight newborns born at our hospital between January 2008 and December 2016; and prospectively, performing a structural brain analysis using magnetic resonance imaging and a cognitive performance study using the Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V).

Results:

The study population consisted of 48 children with an average age of 110.7 months (95 % CI 102.6-118.8) with a history of prematurity and a birthweight of less than 1500g. Of these children, nine had suffered FGR. FGR is associated with a significantly smaller medial orbitofrontal cortex and a significantly larger anterior cingulate cortex. The surface area of the medial orbitofrontal cortex of both hemispheres is significantly associated with the scores obtained in the WISC-V test for verbal comprehension and visual-spatial index.

Conclusions:

FGR and birthweight are both related to structural alterations in the frontal lobe. The surface area of the orbitofrontal cortex is strongly influenced by the weight at birth.

Palabras clave:

Restricción del crecimiento fetal Lóbulo frontal Neurodesarrollo Corteza orbitofrontal

Más Videos Relacionados

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

Videos de Conceptos Relacionados

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...