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Updated: Jan 7, 2026

Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
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Inhibición de Mpro y PLpro del SARS-CoV-2 mediante el reposicionamiento de fármacos aprobados clínicamente

Qiaoyu Fang1, Meng Lu1, Derong Chen1

  • 1Shenzhen Center for Chronic Disease Control and Prevention, Shenzhen Institute of Dermatology, Shenzhen 518020, China.

Viruses
|December 31, 2025
PubMed
Resumen

Dos fármacos existentes, la oxitocina y el risedronato de sodio, muestran potencial para el tratamiento de infecciones por SARS-CoV-2 al inhibir proteasas virales clave (Mpro y PLpro), lo que ralentiza la replicación del virus.

Palabras clave:
MproPLproSARS-CoV-2fármacos cefalosporínicosoxitocina

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