Video Experimental Relacionado
Updated: Jan 7, 2026
07:09
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
2.3K
Disfunción tiroidea en la insuficiencia cardíaca con fracción de eyección preservada: una revisión sistemática y
Maryam Heidarpour1, Mania Banar1, Amir Parsa Abhari2
1Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
ARYA atherosclerosis
|December 31, 2025
Resumen
La disfunción tiroidea es común en pacientes con insuficiencia cardíaca con fracción de eyección preservada (ICFEp). Esta revisión sistemática encontró una prevalencia del 15% de disfunción tiroidea manifiesta y del 22% para el síndrome de T3 baja en pacientes con ICFEp.
Área de la Ciencia:
- Cardiología
- Endocrinología
- Medicina Interna
Sus antecedentes:
- Se asume a menudo que la disfunción tiroidea está relacionada con la insuficiencia cardíaca con fracción de eyección preservada (ICFEp).
- La investigación existente sobre hormonas tiroideas y ICFEp presenta hallazgos controvertidos.
- Este estudio revisa sistemáticamente la literatura para determinar la prevalencia de disfunción tiroidea en pacientes con ICFEp.
Objetivo del estudio:
- Revisar sistemáticamente y estimar la prevalencia de disfunción tiroidea en pacientes diagnosticados con ICFEp.
- Analizar la prevalencia de disfunción tiroidea manifiesta, síndrome de T3 baja e hipotiroidismo subclínico (HCS) en ICFEp.
- Evaluar la asociación entre la disfunción tiroidea y la gravedad y los resultados de la ICFEp.
Principales métodos:
- Se realizó una búsqueda exhaustiva de la literatura en las principales bases de datos (PubMed, Scopus, Web of Science, Embase, ProQuest) hasta noviembre de 2024.
- Se incluyeron estudios observacionales centrados en la prevalencia de disfunción tiroidea en pacientes con ICFEp.
- La prevalencia combinada se calculó utilizando un modelo de efectos aleatorios, con el sesgo de publicación evaluado mediante la prueba Trim and Fill, el gráfico de embudo y la prueba de Egger.
Principales resultados:
- El análisis incluyó 14 estudios con 3.931 sujetos con ICFEp.
- La prevalencia combinada de disfunción tiroidea manifiesta fue del 15% (IC del 95%: 7%-29%).
- Las tasas de prevalencia fueron del 22% (IC del 95%: 20%-25%) para el síndrome de T3 baja y del 15% (IC del 95%: 1%-68%) para el hipotiroidismo subclínico (HCS).
Conclusiones:
- La disfunción tiroidea parece ser una comorbilidad común en pacientes con ICFEp.
- A pesar de la heterogeneidad del estudio, los hallazgos sugieren un vínculo potencial entre la disfunción tiroidea y los síntomas más graves de ICFEp.
- La disfunción tiroidea puede estar asociada con peores resultados en personas con ICFEp.
Videos de Conceptos Relacionados
01:27Heart Failure I: Introduction
657
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
657
01:17Pathophysiology of Heart Failure
2.7K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.7K
01:29Heart Failure II: Pathophysiology
663
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
663
01:22Heart Failure Drugs: β-Blockers
727
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
727
01:30Heart Failure V: Medical Management
196
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
196
01:22Heart Failure Drugs: Diuretics
763
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
763