Video Experimental Relacionado

Updated: Jun 12, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Microplásticos de poliestireno modulan los efectos tóxicos del bisfenol A en las primeras etapas del desarrollo de

Alessandra La Pietra¹, Teresa Mobilio¹, Gianluca Fasciolo¹

¹Department of Biology, University of Naples Federico II, Naples, Italy.

Environmental toxicology and pharmacology

|December 31, 2025

Abstract:

One of the characteristics of polystyrene microplastics (PS-MPs) is their hydrophobic surface, which allows them to carry other pollutants such as bisphenol A (BPA), known to be endocrine disruptor. This study investigated the co-exposure of 1µm PS-MPs at 1.0 mgL^-1 with BPA at 25.0µM on zebrafish development. The results on the toxicity parameters showed that PS-MPs and BPA during co-exposure had antagonist effects reducing their effects compared to single exposure, in hatching, neurotoxicity and heart rate. This trend was confirmed by an improvement in the expression of developmental genes observed in the co-exposed group. However, in redox homeostasis analysis emerged that, when together, PS-MPs exacerbated the effects of BPA compared to single exposure in redox homeostasis analysis. The findings showed a dual role of PS-MPs in modulating the effects of BPA providing new information on the risk associated with their simultaneous presence in the aquatic environment.

Palabras clave:

Cebrafish bisfenol A coexposición toxicidad embrionaria microplásticos de poliestireno

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