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Updated: Jan 7, 2026
08:36
Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
Published on: July 12, 2012
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Del intestino al cerebro: transporte, función y toxicidad del micronutriente esencial y oligoelemento manganeso
Jiaqi Zou1, Riya Yerramilli1, Tolunay Beker Aydemir1
1Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
Frontiers in physiology
|January 1, 2026
Resumen
Esta revisión detalla el metabolismo del manganeso (Mn), cubriendo su absorción, transporte y regulación. Enfatiza el Mn
Área de la Ciencia:
- Fisiología
- Neurociencia
- Toxicología
Sus antecedentes:
- El manganeso (Mn) es esencial pero tóxico en exceso.
- La desregulación de la homeostasis del Mn está relacionada con trastornos neurológicos.
Objetivo del estudio:
- Revisar exhaustivamente el metabolismo y la regulación del Mn.
- Explorar los mecanismos de transporte del Mn y su papel en la salud y la enfermedad.
Principales métodos:
- Revisión bibliográfica de la absorción, excreción, distribución y transporte del Mn.
- Análisis de factores genéticos y ambientales que influyen en la homeostasis del Mn.
- Enfoque en la neurotoxicidad del Mn y sus mecanismos.
Principales resultados:
- La homeostasis del Mn implica interacciones complejas entre los intestinos, el hígado y el cerebro.
- Los transportadores de metales desempeñan funciones críticas en la regulación sistémica y cerebral del Mn.
- La desregulación del Mn contribuye a las enfermedades neurodegenerativas.
Conclusiones:
- La comprensión del transporte del Mn es clave para controlar la homeostasis del Mn.
- Esta revisión une los mecanismos moleculares con la fisiología de todo el cuerpo.
- La investigación adicional sobre los transportadores de Mn puede informar el tratamiento de enfermedades.
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