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Análisis estructural y modelado de inhibidores de la bacterioferritina de Brucella abortus

Lijun Liu1,2, Elizabeth K Harmon2,3, Justin K Craig2,3

  • 1Protein Structure and X-Ray Crystallography Laboratory, Del Shankel Structural Biology Center, University of Kansas, Kansas, USA.

Proteins
|January 2, 2026
PubMed
Resumen

No abstract available in PubMed .

Palabras clave:
Bacterioferritina y sus derivadosLa brucelosisEnlace con el inhibidortransporte de hierropatógenoscomplejo de proteínas

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Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
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