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Updated: Jun 16, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Establecimiento de un protocolo de diseño racional combinado para el descubrimiento de nuevos enlaces peptídicos de

Shichun Wu1, Zhenxing Yu1, Shishui Guan1

  • 1Department of Orthopedics, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, 363000, Fujian Province, China.

Molecular diversity
|January 3, 2026
PubMed
Resumen

No abstract available in PubMed .

Palabras clave:
Factor de crecimiento de fibroblastos 7Aprendizaje automáticoAcoplamiento molecularAglutinantes de péptidosDiseño terapéutico

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...