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Updated: Jan 7, 2026

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miR-376c-3p media el efecto anti-osteoclastogénico de la icariina mediante la orientación hacia Mmp3

Hui Yan1,2,3, Jingdi Li1,2,3, Dingbang Xie1,2,3

  • 1Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Journal of orthopaedic surgery and research
|January 4, 2026
PubMed
Resumen

No abstract available in PubMed .

Palabras clave:
Icariína y sus derivadosMetabolismo de las proteínas de matrizOsteoclastogénesisOsteoporosis después de la menopausiaMiR-376c-3p y sus derivados

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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