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Updated: Jan 13, 2026

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Ingeniería de la galactósido acetiltransferasa para mejorar la biodisponibilidad de la hesperetina-7-O-glucósido

Jia-Xin Wang1, Zi-Feng Lin2, Xin-Yu Zheng1

  • 1School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.

Applied microbiology and biotechnology
|January 6, 2026
PubMed
Resumen

La acetilación enzimática de glucósidos de flavonoides por la galactósido acetiltransferasa (GAT) mejora significativamente su biodisponibilidad. La ingeniería de proteínas de la GAT, específicamente la mutación P148A, mejoró la eficiencia catalítica para una mejor absorción.

Palabras clave:
análisis ANCIingeniería de acetiltransferasaoptimización de biodisponibilidadglucósido de flavonoidesimulación MD

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