Video Experimental Relacionado

Updated: Jan 13, 2026

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

TEPEAK: Un método novedoso para identificar y caracterizar elementos transponibles polimórficos en poblaciones de

Devin Burke¹, Jishnu Raychaudhuri¹, Edward Chuong^1,2

¹BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, United States of America.

PLoS computational biology

|January 6, 2026

Abstract:

Transposable elements (TEs) replicate within genomes and are an active source of genetic variability in many species. Their role in immunity and domestication underscores their biological significance. However, analyzing TEs, especially within lesser-studied and wild populations, poses considerable challenges. To address this, we introduce TEPEAK, a simple and efficient approach to identify and characterize TEs in populations without any prior sequence or loci information. In addition to processing user-submitted genomes, TEPEAK integrates with the National Center for Biotechnology Information (NCBI) Sequence Read Archive (SRA) to increase cohort sizes or incorporate proximate species. Our application of TEPEAK to 257 horse genomes spanning 11 groups reaffirmed established genetic histories and highlighted disruptions in crucial genes. Some identified TEs were also detectable in species closely related to horses. TEPEAK paves the way for comprehensive genetic variation analysis in traditionally understudied populations by simplifying TE studies. TEPEAK is open-source and freely available at https://github.com/ryanlayerlab/TEPEAK.

Palabras clave:

elementos transponibles variación genética genómica de poblaciones caballos especies no modelo

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