Video Experimental Relacionado
Updated: Jan 13, 2026
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
Hemodinámica cerebral y conectividad funcional en la prueba de Stroop en pacientes con enfermedad de Parkinson: un
Liping Qi1, Zi-Qian Shi2, Yan-Zhi Liu3
1School of Control Science and Engineering, Dalian University of Technology, Dalian, 116024, China.
Background:
Cognitive impairment is a core non-motor feature of Parkinson's disease (PD). This study aimed to: (1) assess PD patients' performance on the color-word Stroop task and characterize task-related neural activity; (2) develop PD diagnostic models using task-based functional near-infrared spectroscopy (fNIRS) features to link neuroimaging mechanisms with clinical translation.
Methods:
Sixty-one participants (29 PD patients, 32 healthy controls [HC]) completed the Stroop task during fNIRS recording. Cerebral hemodynamic and brain network analyses were performed, and a two-way ANCOVA examined group (PD vs. HC) and task (congruent vs. incongruent stimuli) effects, adjusted for Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Machine learning frameworks were applied to construct diagnostic models using task-based fNIRS features.
Results:
PD patients showed significantly higher omission rates than HC across both Stroop conditions, alongside enhanced dorsolateral prefrontal cortex and frontal eye field activation, and increased prefrontal interhemispheric functional connectivity. Logistic regression outperformed other models, achieving comparable accuracy with fewer features.
Conclusion:
These findings advance our understanding of PD-related cognitive impairment and provide a framework for developing non-invasive, objective diagnostic tools.
