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Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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The Cell Cycle Control System01:28

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Biological Clocks and Seasonal Responses02:45

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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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Molecular Factors Affecting Cell Division01:27

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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
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M-Cdk Drives Transition Into Mitosis02:15

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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
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Video Experimental Relacionado

Updated: Jan 13, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Los relojes biológicos vigilan la mitosis

Colin Richard Gliech1, Andrew Jon Holland2

  • 1Division of Rheumatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Nature cell biology
|January 6, 2026
PubMed
Resumen

La segregación cromosómica precisa es crucial para prevenir el cáncer. Este estudio explora nuevos

Palabras clave:
relojes biológicosmitosissegregación cromosómicatumorigénesisintegridad genómica

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Área de la Ciencia:

  • Biología celular
  • Genómica
  • Investigación del cáncer

Sus antecedentes:

  • La segregación cromosómica precisa es esencial para prevenir anomalías del desarrollo y el cáncer.
  • Los errores en la división celular están relacionados con la tumorigénesis.
  • Los mecanismos de salvaguardia, o relojes mitóticos, mantienen la fidelidad durante la división celular.

Objetivo del estudio:

  • Revisar los avances recientes en la comprensión de la cronología mitótica.
  • Presentar la evidencia emergente de nuevos relojes mitóticos.
  • Proponer un marco para cómo las células utilizan las señales temporales para mantener la integridad genómica.

Principales métodos:

  • Revisión y síntesis de la literatura sobre hallazgos de investigación recientes.
  • Análisis de evidencia emergente sobre nuevos relojes mitóticos.
  • Desarrollo de un marco conceptual basado en la comprensión actual.

Principales resultados:

  • Los avances recientes han profundizado la comprensión de la cronología mitótica.
  • La evidencia emergente sugiere la existencia de nuevos relojes mitóticos.
  • Se propone un marco conceptual para integrar las señales temporales en la división celular.

Conclusiones:

  • Comprender la cronología mitótica es clave para prevenir la tumorigénesis.
  • Los nuevos relojes mitóticos pueden representar nuevos objetivos terapéuticos.
  • La integración de las señales temporales es vital para preservar la integridad genómica.