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Aneurisma de aorta abdominal y riesgo de gota: un estudio de cohorte observacional a nivel nacional basado en la
Kang Woong Jun1, Kyung-Jai Ko2, Hyung-Jin Cho3
1Department of Surgery, Division of Vascular and Transplant Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Medicine
|January 7, 2026
Resumen
El aneurisma de la aorta abdominal (AAA) aumenta el riesgo de gota. La reparación quirúrgica, especialmente la reparación endovascular de aneurismas (EVAR), eleva aún más este riesgo, lo que resalta la necesidad de monitorización metabólica en pacientes con AAA.
Área de la Ciencia:
- Medicina Cardiovascular; Reumatología; Trastornos Metabólicos
Sus antecedentes:
- La inflamación sistémica en el aneurisma de la aorta abdominal (AAA) puede estar relacionada con trastornos metabólicos. La relación entre el AAA y el desarrollo de gota requiere una mayor investigación. Es crucial comprender los impactos del tratamiento en el riesgo de gota en pacientes con AAA.
Objetivo del estudio:
- Determinar si el aneurisma de la aorta abdominal (AAA) es un factor de riesgo para el desarrollo de gota. Evaluar la influencia de diferentes estrategias de tratamiento del AAA en el riesgo de gota. Informar los protocolos de monitorización metabólica para pacientes con AAA.
Principales métodos:
- Estudio de cohorte retrospectivo a nivel nacional utilizando datos del Servicio Nacional de Seguro de Salud de Corea (2009-2015). 14.256 pacientes con AAA emparejados con 42.768 controles (relación 1:3) por edad y sexo. Se identificó la gota incidente y se analizó utilizando modelos de regresión de Cox de riesgos proporcionales.
Principales resultados:
- La incidencia de gota fue significativamente mayor en pacientes con AAA (21,75 por 1000 personas-año) en comparación con los controles (13,87 por 1000 personas-año). El AAA se asoció de forma independiente con un mayor riesgo de gota (HR: 1,443, IC del 95%: 1,325-1,573) después de los ajustes. La intervención quirúrgica (HR: 1,795) y la EVAR (HR: 1,862) mostraron mayores riesgos de gota en comparación con los controles sin AAA.
Conclusiones:
- El aneurisma de la aorta abdominal (AAA) es un factor de riesgo independiente para el desarrollo de gota. El tratamiento quirúrgico del AAA, en particular la EVAR, eleva aún más el riesgo de desarrollar gota. Se recomienda una monitorización metabólica mejorada para los pacientes con AAA, especialmente después de la EVAR.
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