Un método novedoso para la detección del antígeno Tn basado en el marcado dirigido quimioenzimático y la química click de CuAAC

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Updated: Jan 13, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

Hongxia Duan¹, Lei Liu^2,3, Xin Guo¹

¹MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, 116024, China. dongmm@dlut.edu.cn.

Chemical communications (Cambridge, England)

|January 7, 2026

Abstract:

The Tn antigen is a key tumor-associated antigen and a promising cancer biomarker. However, its low abundance poses great challenges for sensitive detection. We developed a novel approach that integrates B3GNT6-mediated Tn-specific labelling, click chemistry, and chemiluminescence detection to enable quantitative and sensitive analysis of Tn antigen.

Palabras clave:

antígeno Tn biomarcador del cáncer química click quimioluminiscencia B3GNT6 análisis cuantitativo

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