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Ácido Nucleico Tetrahédrico Estructural (tFNA) basado en Cepharanthine para la Modulación de la Vía cGAS-STING-NF-κB

Shibo Liu¹, Hanghang Liu^1,2, Qiheng Yang¹

¹State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.

ACS applied materials & interfaces

|January 7, 2026

Resumen

Una nueva plataforma nanomédica (tFNA@Cep) trata eficazmente la osteoartritis temporomandibular (TMJOA) al reducir la inflamación y promover la reparación del cartílago. Esta nanoterapiéutica ofrece una estrategia prometedora para la TMJOA y otros trastornos articulares.

Área de la Ciencia:

Biomedical Engineering
Nanotechnology
Osteoarthritis Research

Sus antecedentes:

Temporomandibular joint osteoarthritis (TMJOA) is a degenerative condition with limited effective treatments.
Characterized by cartilage degradation, bone remodeling, and inflammation, TMJOA significantly impacts patient quality of life.

Objetivo del estudio:

To develop and evaluate a novel cepharanthine-loaded tetrahedral framework nucleic acid nanoplatform (tFNA@Cep) for TMJOA treatment.
To assess the physicochemical properties, biological performance, and therapeutic efficacy of tFNA@Cep in a murine TMJOA model.

Principales métodos:

Fabrication and characterization of the tFNA@Cep nanoplatform.
Induction of TMJOA in a murine model using unilateral anterior crossbite.
Evaluation of therapeutic effects on cartilage, subchondral bone, and inflammatory pathways.

Principales resultados:

tFNA@Cep demonstrated excellent stability, cellular uptake, and structural integrity.
Treatment significantly improved cartilage thickness and subchondral bone, restoring Col II and RUNX2 expression.
tFNA@Cep modulated macrophage polarization to an anti-inflammatory M2 phenotype, suppressed the cGAS-STING-NFκB pathway, and reduced ROS production.

Conclusiones:

tFNA@Cep acts as a multifunctional nanotherapeutic agent for TMJOA.
It effectively integrates drug delivery, inflammation resolution, and osteochondral repair.
This nanoplatform presents a promising therapeutic strategy for TMJOA and related joint diseases.

Palabras clave:

vía cGAS−STING cepharanthine reprogramación de macrófagos osteoartritis temporomandibular ácido nucleico tetrahédrico estructural

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