Video Experimental Relacionado

Updated: Jan 13, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

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Suplementación con alfa-cetoglutarato mejora la hiperglucemia y atenúa la disminución de las proteínas GLUT4 y PGC-1α

Ai Takemura1,2, Yutaka Matsunaga1,3, Shota Hajime1

  • 1Department of Sports Sciences, The University of Tokyo, Tokyo, Japan.

Journal of nutritional science
|January 7, 2026
PubMed
Resumen

El alfa-cetoglutarato (AKG) mejora el metabolismo de la glucosa en ratones diabéticos. La suplementación con AKG mejoró la biogénesis mitocondrial y los niveles del transportador de glucosa en el tejido adiposo, ayudando al control de la glucosa en todo el cuerpo.

Palabras clave:
AKGalfa-cetoglutaratoAMPKAMP quinasa activadaATP5Asintasa de ATPH+ transportadoracomplejo F1 mitocondrialsubunidad αTejidos adipososalfa-cetoglutaratoBATtejido adiposo marrónBCAAaminoácido de cadena ramificadaBCAT2transaminasas de BCAA 2BCKAscetoácidos de cadena ramificadaCONcontrolDMdiabetesDiabetesELISAensayo de inmunoabsorción ligado a enzimasGLUT4transportador de glucosa 4HFDdieta alta en grasasHOMA-IRmodelo de evaluación homeostática de la resistencia a la insulinaICRInstituto de Investigación del CáncerNDUFB8subunidad 1β de la NADH deshidrogenasa (ubiquinona)OXPHOSfosforilación oxidativaPGC-1αcoactivador 1 alfa del receptor activado por proliferadores de peroxisomas γPRDM16proteína 16 que contiene el dominio RIZ1-BF-1-PRD1 homólogoSDdesviación estándarSDHBsubunidad B del complejo de succinato deshidrogenasaSTZestreptocinaMúsculos esqueléticosT2DMdiabetes mellitus tipo 2TAtibial anteriorUCP1proteína desacoplante 1UQCRC2proteína central II de la ubiquinol-citocromo c reductasamTORC1complejo 1 de diana de rapamicina de la दिर

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