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Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
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Disfunción glinfática impulsada por neuroinflamación: implicaciones para la progresión de la enfermedad y la
Syeda Tayyaba Batool1, Umair Ali2, Muhammad Ijaz Khan2
1Department of Medicine, Azad Jammu and Kashmir Medical College, Muzaffrabad, Pakistan.
Abstract:
The glymphatic system plays a critical role in central nervous system waste clearance, and its impairment is increasingly linked to neuroinflammation and accelerated disease progression. The latest 2025 evidence reveals that inflammatory microglial activation, perivascular aquaporin-4 disorganization, and impaired cerebrospinal fluid-interstitial fluid exchange contribute to dysfunctional neuro-clearance, fostering protein aggregation and neuronal injury. Emerging data also highlight the potential for drug-mediated modulation of glial metabolism, vascular inflammation, and aquaporin-4 stability to support early neuro-barrier protection and glymphatic flow recovery.
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