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Lactobacillus modificado que expresa citocinas antitumorales: una nueva bioterapia

Muhammad Shahid Mehmood¹, Maryam Abid², Fatima Hajj³

¹Faculty of Veterinary Science, Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan.

Annals of medicine and surgery (2012)

|January 7, 2026

Resumen

Los probióticos de Lactobacillus modificados que expresan citocinas antitumorales ofrecen una nueva terapia contra el cáncer. Estos microbios modificados reducen eficazmente el crecimiento tumoral y mejoran la respuesta inmunitaria, proporcionando una alternativa más segura a los tratamientos sistémicos con citocinas.

Área de la Ciencia:

Oncología; Ingeniería del Microbioma; Biología Sintética

Sus antecedentes:

Los tumores sólidos causan casi el 90% de las muertes por cáncer a nivel mundial.

Objetivo del estudio:

Investigar el potencial de las cepas de Lactobacillus modificadas como una nueva bioterapia para el tratamiento del cáncer.

Principales métodos:

Modificación de cepas de Lactobacillus para expresar citocinas específicas (IL-12, IL-15, TRAIL).

Principales resultados:

Lactobacillus plantarum que secreta IL-12 redujo el volumen del tumor colorrectal en un 65%.

Conclusiones:

Los probióticos de Lactobacillus modificados pueden reducir eficazmente la carga tumoral y mejorar la inmunidad antitumoral, imitando la eficacia de la terapia sistémica con citocinas.

Palabras clave:

IL-12 IL-15 TRAIL inmunoterapia contra el cáncer administración de citocinas Lactobacillus modificado probióticos oncología traslacional

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