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Updated: Jan 13, 2026
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Isolation, Processing and Analysis of Murine Gingival Cells
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Interacción entre la supervivencia y los mecanismos de muerte celular regulada durante la progresión de la
Alfredo Torres1,2, Leonardo Díaz3,4,5, Jaime Oyarzún1
1Laboratory of Experimental Immunology & Cancer, Faculty of Dentistry, University of Chile, Santiago, Chile.
The Japanese dental science review
|January 7, 2026
Resumen
Las vías de muerte celular regulada (RCD) son clave en la progresión de la enfermedad periodontal. La focalización de los mecanismos de RCD ofrece nuevas terapias potenciales para reducir la inflamación y el daño tisular en la periodontitis.
Área de la Ciencia:
- Periodoncia
- Biología Celular
- Inmunología
Sus antecedentes:
- Las vías de muerte celular regulada (RCD) y supervivencia influyen significativamente en la degradación de los tejidos periodontales.
- Los roles e interacciones exactos de estas vías en la progresión de la periodontitis no se comprenden completamente.
Objetivo del estudio:
- Revisar sistemáticamente y sintetizar la evidencia actual sobre la participación de la RCD y los mecanismos de supervivencia en la progresión de la periodontitis.
- Consolidar el papel fundamental de la RCD en la periodontitis y explorar estrategias terapéuticas potenciales.
Principales métodos:
- Se realizó una búsqueda sistemática de literatura en las principales bases de datos (PubMed/MEDLINE, Web of Science, Scopus) y Google Scholar, siguiendo las directrices PRISMA.
- La selección de 549 estudios únicos, seguida de la revisión de texto completo de 56 artículos, condujo a la inclusión de 18 estudios en la síntesis final.
- La mayoría de los estudios incluidos utilizaron modelos animales de periodontitis inducida por ligadura.
Principales resultados:
- La ferroptosis, la piroptosis y la necroptosis se vincularon consistentemente con un aumento de la inflamación, la pérdida ósea alveolar y la progresión de la periodontitis.
- La autofagia y la apoptosis mostraron roles dependientes del contexto, actuando como mecanismos protectores o destructivos.
- La modulación de vías específicas de RCD mostró potencial terapéutico para controlar la inflamación y promover la regeneración de tejidos periodontales.
Conclusiones:
- Las vías de RCD desempeñan un papel fundamental en la progresión de la periodontitis.
- La focalización de las vías de RCD presenta prometedoras estrategias terapéuticas novedosas para el manejo de la periodontitis.
- Estos hallazgos resaltan estrategias traslacionales potenciales para la terapia de modulación del huésped en la periodontitis.
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