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Dupilumab-Induced Systemic Hypoperfusion in an Elderly Patient: A Case Report
Huishang Feng1,2, Yao Liu3, Xinglu Dong4
1Department of Dermatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Journal of inflammation research
|January 7, 2026
Resumen
Dupilumab, used for bullous pemphigoid, may rarely cause stroke in elderly patients due to hypotension. Careful monitoring and hydration after injections are recommended for high-risk individuals.
Área de la Ciencia:
- Neurología; Farmacología; Inmunología
Sus antecedentes:
- Dupilumab es un tratamiento reconocido para el penfigoide ampolloso (BP).; Este informe detalla un evento adverso raro potencialmente relacionado con dupilumab.; El caso involucra a un paciente de edad avanzada con comorbilidades múltiples.
Objetivo del estudio:
- Informar el primer caso de infarto cerebral recurrente inducido por hipoperfusión asociado con dupilumab.; Investigar la posible relación entre dupilumab y eventos cerebrovasculares.; Destacar la necesidad de vigilancia en poblaciones de pacientes específicas.
Principales métodos:
- Un informe de caso de un hombre de 96 años con BP que recibe dupilumab.; Observación clínica de eventos neurológicos posteriores a las inyecciones de dupilumab.; Análisis de la asociación temporal y la probabilidad de reacción adversa a los medicamentos.
Principales resultados:
- El paciente experimentó infartos cerebrales recurrentes y ataques isquémicos transitorios temporalmente relacionados con dupilumab.; Se observaron hipotensión y depresión de la conciencia después de la inyección.; La hidratación profiláctica pareció prevenir el infarto en una ocasión.
Conclusiones:
- Existe una asociación probable entre dupilumab y el infarto cerebral inducido por hipoperfusión en este paciente de edad avanzada de alto riesgo.; Sugiere monitorización de la presión arterial y manejo de líquidos post-inyección para personas en riesgo.; Destaca la necesidad de una mayor investigación sobre la seguridad de dupilumab en poblaciones de edad avanzada.
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