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Updated: Jan 13, 2026

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Virus y el replisoma del huésped: descubrimiento de mecanismos oncogénicos de pequeños virus de tumores de ADN

Christopher D Collins^1,2,3, Matthew Stefely², Kavi Prem Milan Mehta⁴

¹John W. and Jeanne M. Rowe Center for Research in Virology, Madison, Wisconsin, USA.

Journal of virology

|January 7, 2026

Abstract:

Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) are DNA tumor viruses that cause human cancer. The mechanisms by which HPV and MCPyV oncoproteins induce genomic instability are not well defined. This minireview discusses the influence of these oncoproteins on the repertoire of proteins at replicating DNA, known as the host replisome, and discusses how new technologies like isolation of proteins on nascent DNA (iPOND) can drive the discovery of viral dysregulation of the host replisome to enhance our understanding of viral oncogenesis.

Palabras clave:

daño del ADN reparación del daño del ADN replicación del ADN virus de tumores de ADN poliomavirus de células de Merkel replisoma del huésped virus del papiloma humano iPOND oncoproteínas virales

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