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El Navegador Genómico Global de Genética de la Enfermedad de Parkinson (GP2)

Zih-Hua Fang^1,2, Riley H Grant³, Dan Vitale^1,4

¹DataTecnica, Washington, DC, USA.

medRxiv : the preprint server for health sciences

|January 8, 2026

Abstracto

Background:

Large-scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease-causing variants, we developed an open-access, summary-level genomic data browser.

Methods:

We performed uniform joint variant calling to harmonize whole-genome sequencing (WGS) data from AMP-PD Release 4, GP2 Data Releases, and additional controls from the Alzheimer's Disease Sequencing Project. Clinical exome sequencing (CES) data from GP2 Release 8 was also included.

Results:

The integrated dataset includes 31,665 WGS and 9,559 CES samples, spanning eleven ancestries and over 300 million variants.

Conclusion:

The GP2 Genome Browser is a lightweight, flexible platform providing intuitive gene- and variant-level summaries with ancestry-stratified allele frequencies and functional annotations. It is open source and freely accessible at https://gp2.broadinstitute.org, enabling broad access to PD genomic data and supporting global research efforts.

Palabras clave:

Enfermedad de Parkinson navegador genética secuenciación

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