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¿Podemos escapar de los patógenos ESKAPE de máxima prioridad?

Lingbing Zeng1, YouJun Feng2, Minggui Wang3

  • 1Department of Laboratory Medicine and Branch of Gaoxin, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Emerging microbes & infections
|January 8, 2026
PubMed
Resumen
Este resumen es generado por máquina.

Los patógenos ESKAPE son organismos críticos multirresistentes que impulsan la crisis mundial de resistencia a los antimicrobianos. Combatir estas superbacterias requiere estrategias integradas centradas en la prevención, la vigilancia y las terapias novedosas.

Palabras clave:
resistencia a los antimicrobianospatógenos ESKAPEsuperbacteriassalud mundialinfeccionesterapias novedosas

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Área de la Ciencia:

  • Microbiología
  • Enfermedades Infecciosas
  • Salud Pública

Sus antecedentes:

  • Los patógenos ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa y Enterobacter spp.) son organismos críticos de máxima prioridad multirresistentes.
  • Estas bacterias contribuyen significativamente a la crisis mundial de resistencia a los antimicrobianos, aumentando la morbilidad, la mortalidad y los costos de atención médica.
  • La capacidad de los patógenos ESKAPE para evadir los antibióticos convencionales complica el manejo clínico y el control de infecciones.

Objetivo del estudio:

  • Resumir la evidencia reciente sobre la carga y prevalencia de las infecciones por ESKAPE.
  • Evaluar las estrategias emergentes para combatir la resistencia a los antimicrobianos que plantean estos patógenos.
  • Destacar la necesidad de enfoques integrados para mitigar la amenaza de los patógenos ESKAPE.

Principales métodos:

  • Mini revisión de la literatura científica reciente.
  • Análisis de la evidencia sobre la carga y prevalencia de las infecciones por ESKAPE.
  • Evaluación de las estrategias terapéuticas y de vigilancia emergentes.

Principales resultados:

  • Los patógenos ESKAPE representan una amenaza significativa para la salud mundial debido a la multirresistencia.
  • Las estrategias emergentes muestran promesa en estudios preclínicos y clínicos.
  • Los enfoques integrados que combinan prevención, vigilancia e innovación terapéutica son cruciales.

Conclusiones:

  • Se necesitan intervenciones coordinadas y sostenidas para abordar la amenaza global de los patógenos ESKAPE.
  • El progreso en la vigilancia y las terapias novedosas indica un camino a seguir.
  • Un énfasis equilibrado en la prevención, la vigilancia y la innovación terapéutica es esencial para la próxima década.