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Perfil de microARNs en coinfección por malaria y arbovirus: protocolo de revisión sistemática
Andrillene Laure Deutou Wondeu1, Alex Durant Nka2, Aude Christelle Ka'e2
1The Laboratory for Public Health Research Biotechnologies, MARCAD Plus Program, The Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon.
PloS one
|January 8, 2026
Resumen
Esta revisión sistemática examina los microARNs (miARN) en coinfecciones por malaria y arbovirus, como el virus del Dengue (DENV), el virus de la chikungunya (CHIKV) y el virus Zika (ZIKV). Los hallazgos iluminarán los mecanismos de la enfermedad e identificarán biomarcadores para diagnóstico y terapéutica.
Conclusiones:
- Los hallazgos avanzarán la comprensión de la patogénesis de la coinfección.
- Los perfiles de miARN identificados pueden servir de base para nuevos enfoques terapéuticos, incluidos sistemas de administración basados en nanopartículas.
- Establece una base para futuros estudios de validación funcional de miARNs de origen vegetal.
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