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Asociación entre lípidos séricos y pólipos colorrectales: un estudio transversal retrospectivo

Maolang He¹, Shuxin Tian¹, Shangqi Wang²

¹Department of Gastroenterology, The First Affiliated Hospital of Shihezi University, Shihezi, 832008, China.

International journal of colorectal disease

|January 8, 2026

Resumen

Los niveles elevados de triglicéridos y colesterol total se asocian con un mayor riesgo de pólipos colorrectales (PC). La inflamación puede mediar la asociación entre ciertos lípidos y los PC, lo que sugiere biomarcadores potenciales para la evaluación del riesgo.

Área de la Ciencia:

Epidemiología cardiovascular
Gastroenterología
Investigación de biomarcadores

Sus antecedentes:

La asociación entre los lípidos séricos y los pólipos colorrectales (PC) carece de evidencia consistente.
Estudios previos presentan hallazgos contradictorios sobre los perfiles lipídicos y el riesgo de PC.

Objetivo del estudio:

Investigar la relación entre los niveles de lípidos séricos y el riesgo de pólipos colorrectales utilizando datos del mundo real.
Explorar el papel mediador potencial de la inflamación en la asociación lípidos-PC.

Principales métodos:

Análisis retrospectivo de datos clínicos de 2015-2024.
Aplicación de regresión logística multivariante y análisis de splines cúbicos restringidos (RCS).
Examen de índices relacionados con la inflamación como posibles mediadores.

Principales resultados:

Se encontraron asociaciones positivas entre los triglicéridos (TG) y el colesterol total (CT) con el riesgo de PC.
Se identificó una relación dosis-respuesta no lineal entre los TG y el riesgo de PC, con un umbral de 0,93 mmol/L.
La inflamación medió la relación entre las lipoproteínas de alta densidad, el CT y el riesgo de PC; se observaron interacciones de género.

Conclusiones:

Los niveles séricos de TG y CT pueden servir como biomarcadores modificables y clínicamente útiles para el riesgo de pólipos colorrectales.
Se necesita más investigación prospectiva para confirmar los hallazgos y explorar intervenciones que modifiquen los lípidos en personas en riesgo.

Palabras clave:

Pólipos colorrectales Estudio transversal Inflamación Factor de riesgo Lípidos séricos

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