Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

5.3K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
5.3K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

2.3K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.3K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

6.9K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
6.9K
Direct Motor Pathways01:11

Direct Motor Pathways

4.1K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
4.1K
Brainstem01:19

Brainstem

5.7K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
5.7K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

2.4K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
2.4K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Characterization of Electrophysiological and Transcriptomic Alterations in Patient-Derived Neurons from CHAMP1 Syndrome.

bioRxiv : the preprint server for biology·2026
Same author

Foreign Body Ingestion in Children.

American family physician·2026
Same author

Premyelinating Oligodendrocyte Survival Governs CNS Remyelination.

bioRxiv : the preprint server for biology·2026
Same author

Nonuniform spike count shared variability in the mouse early visual system.

Journal of neurophysiology·2026
Same author

Timing is everything: myelin and coincidence detection.

Trends in neurosciences·2026
Same author

Time-delay reservoir for signal demixing using Kalman weight updates in fixed point and limit cycle regimes.

Scientific reports·2026

Video Experimental Relacionado

Updated: Jan 13, 2026

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
06:04

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

Published on: March 4, 2014

22.1K

La mielina apoya la función del circuito cortical subyacente al movimiento hábil

Kimberly Gagnon, Gustavo Della Flora Nunes, Dailey Nettles

    bioRxiv : the preprint server for biology
    |January 9, 2026
    PubMed
    Resumen

    La pérdida de mielina en la corteza motora primaria (M1) afecta el movimiento hábil al alterar la actividad y la sincronía neuronal. La disfunción del circuito inhibitorio es un mecanismo clave, incluso después de la remielinización parcial.

    Palabras clave:
    mielinacorteza motora primariamovimiento hábilactividad neuronalesclerosis múltiplecircuitos inhibitoriosremielinización

    Más Videos Relacionados

    Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
    09:41

    Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

    Published on: March 20, 2019

    11.7K
    In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
    07:52

    In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

    Published on: November 22, 2021

    3.8K

    Videos de Experimentos Relacionados

    Last Updated: Jan 13, 2026

    Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
    06:04

    Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice

    Published on: March 4, 2014

    22.1K
    Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
    09:41

    Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

    Published on: March 20, 2019

    11.7K
    In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
    07:52

    In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

    Published on: November 22, 2021

    3.8K

    Área de la Ciencia:

    • Neurociencia
    • Control Motor
    • Biología de la Mielinización

    Sus antecedentes:

    • La corteza motora primaria (M1) es crucial para el movimiento hábil y está densamente mielinizada.
    • La pérdida de mielina, como se observa en la esclerosis múltiple, causa deterioro motor.
    • El papel preciso de la mielinización en la actividad neuronal de M1 durante el comportamiento hábil no se comprende completamente.

    Objetivo del estudio:

    • Investigar cómo la mielinización influye en la actividad y sincronía neuronal en M1 durante el alcance diestro.
    • Identificar los mecanismos celulares y del circuito que vinculan la pérdida de mielina con los déficits motores.

    Principales métodos:

    • Combinación de imágenes in vivo de oligodendrocitos con registros de Neuropixels de alta densidad en ratones durante tareas de alcance.
    • Inducción de desmielinización usando cuprizona.
    • Utilización de un modelo computacional restringido por datos experimentales.

    Principales resultados:

    • La desmielinización inducida por cuprizona afectó la eficiencia del movimiento y alteró la actividad y sincronía neuronal específica de cada tipo de célula.
    • Se identificaron fallos en la propagación axonal inhibitoria como un mecanismo que vincula la pérdida de mielina con la alteración de la función del circuito.
    • La remielinización parcial mejoró las métricas de la red y la consistencia de los alcances, pero no el movimiento suave, lo que indica una vulnerabilidad selectiva en los circuitos inhibitorios.

    Conclusiones:

    • La mielinización es fundamental para apoyar la dinámica del circuito cortical esencial para el comportamiento motor hábil.
    • Los circuitos inhibitorios muestran una vulnerabilidad selectiva a la pérdida de mielina, lo que afecta el control motor.
    • Estos hallazgos conectan los modelos de desmielinización celular con los deterioros motores clínicos.