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Actividad α-glucosidasa de nuevas díadas cumarina-triazol-cumarina

Ersin Şirin¹, Esra Sevimli¹, Gökçe Seyhan²

¹Department of Chemistry, Faculty of Engineering and Natural Sciences, Bursa Technical University, Bursa, Turkiye.

Turkish journal of chemistry

|January 9, 2026

Abstract:

Novel coumarin-triazole-coumarin dyads were synthesized and characterized, and their α-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC₅₀ value of 38.98 ± 0.77 μM. The IC₅₀ values for 4d and 4a were 93.55 ± 1.70 μM and 95.04 ± 3.55 μM, respectively. The Lineweaver-Burk plot showed that 4e inhibited α-glycosidase in a mixed type. In addition, the K _i value obtained from the Dixon plot was 19.95 ± 0.15 μM for α-glycosidase.

Palabras clave:

Cumarina inhibición enzimática triazol α-glucosidasa

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