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Demethylzeylasteral alivia la leucemia mieloide a través de la apoptosis celular mediada por PERK/eIF2α/ATF4/CHOP
Xue Li1, Xianchao He1, Leyan Zhang2
1Medical School of Guizhou University, Guiyang, China.
Translational cancer research
|January 9, 2026
Resumen
La demetilzeylasteral (DML) combate eficazmente la leucemia mieloide induciendo apoptosis a través de la vía PERK/eIF2α/ATF4/CHOP. Este compuesto natural muestra promesa como un nuevo fármaco terapéutico para neoplasias hematológicas.
Sus antecedentes:
- La leucemia mieloide requiere nuevos agentes terapéuticos.
- La demetilzeylasteral (DML), un terpenoide natural, exhibe actividad antitumoral de amplio espectro.
- Los efectos específicos y los mecanismos de la DML en la leucemia mieloide siguen sin explorarse.
Conclusiones:
- La DML induce apoptosis en células de leucemia mieloide.
- El mecanismo implica la activación de la vía de señalización PERK/eIF2α/ATF4/CHOP.
- El estrés del RE y la UPR posterior son mediadores críticos del efecto apoptótico de la DML.
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