Video Experimental Relacionado

Updated: Jan 13, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

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Conmutación de Isoformas de ARHGEF2: Acoplamiento de la Función de Barrera Epitelial Intestinal con la Respuesta

Hans-Christian Reinecker, Shuyuan Chen, Alka Diwaker

    Research square
    |January 9, 2026
    PubMed
    Resumen

    Las células epiteliales utilizan isoformas específicas de GEF-H1 para mantener la integridad de la barrera intestinal y activar la autofagia contra patógenos. Un cambio de isoforma interrumpe esta defensa, causando inflamación y pérdida de polaridad.

    Palabras clave:
    isoformas de GEF-H1barrera epitelial intestinalautofagiadefensa del huéspedListeria monocytogenesinflamaciónpérdida de polaridad

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